Journal article
Relationship between Serum Estradiol Concentrations and Clinical Outcomes in Transgender Individuals Undergoing Feminizing Hormone Therapy: A Narrative Review
BJ Nolan, AS Cheung
Transgender Health | Published : 2021
Abstract
Transgender, including gender diverse and nonbinary, individuals are treated with estradiol with or without antiandrogen to align their physical appearance with their gender identity, improve mental health and quality of life. Consensus guidelines give target ranges for serum estradiol concentration based on premenopausal female reference ranges. However, limited studies have evaluated the relationship between serum estradiol concentrations and clinical outcomes in transgender individuals undergoing feminizing hormone therapy. The available evidence has not found that higher serum estradiol concentrations, together with suppressed testosterone, enhance breast development, or produce more fem..
View full abstractGrants
Awarded by Australian Government National Health and Medical Research Council Early Career Fellowship
Funding Acknowledgements
B.J.N. is supported by the Royal Australasian College of Physicians Fellows Research Entry Scholarship. A.S.C. is supported by an Australian Government National Health and Medical Research Council Early Career Fellowship (#1143333) and receives research support from the Viertel Charitable Foundation Clinical Investigator Award, Endocrine Society of Australia Postdoctoral Award, and the Royal Australasian College of Physicians.